C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 35/76 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) C07K 14/11 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2334850
The present invention relates to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The methods of the invention are particularly attractive for growing viruses suitable for use in vaccine and pharmaceutical formulations.
L'invention concerne de nouveaux procédés et substrats pour la propagation de virus. L'invention concerne des substrats déficients en interféron et des procédés de propagation dans ces substrats non classiques. L'invention concerne, en outre, des procédés de propagation des virus dans des oeufs immatures embryonnés, de préférence des oeufs de poule ayant six à neuf jours. Les procédés de l'invention sont particulièrement attractifs pour la croissance de virus, utilisés dans des formulations pharmaceutiques et des vaccins.
Garcia-Sastre Adolfo
O'neil Robert
Palese Peter
Mount Sinai School Of Medicine
Mount Sinai School Of Medicine Of The City University Of New Yor
Osler Hoskin & Harcourt Llp
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