Novel methods for the treatment of inflammatory diseases

Details Novel methods for the treatment of inflammatory diseases Novel methods for the treatment of inflammatory diseases

C - Chemistry, Metallurgy

07

D

C07D 317/10 (2006.01) A61K 31/085 (2006.01) A61K 31/357 (2006.01) A61K 31/385 (2006.01) A61K 31/39 (2006.01) A61K 31/415 (2006.01) A61K 31/4418 (2006.01) C07C 43/225 (2006.01) C07D 213/69 (2006.01) C07D 231/12 (2006.01) C07D 317/34 (2006.01) C07D 319/06 (2006.01) C07D 327/04 (2006.01) C07D 327/06 (2006.01) C07D 339/06 (2006.01) C07D 411/10 (2006.01)

Patent

CA 2521606

Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.

Cette invention concerne des méthodes permettant d'inhiber la cytokine ou l'activité biologique du facteur d'inhibition de la migration des macrophages (MIF). Cette méthode consiste à mettre en contact un MIF avec un composé représenté par la formule (I). L'invention concerne également des méthodes de traitements de maladies ou d'états impliquant la cytokine MIF ou une activité biologique, qui consiste à administrer des composés de formule (I) soit seuls, soit dans le cadre d'une thérapie combinatoire. Sont également décrits des nouveaux composés représentés par la formule (I).

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