A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01)
Patent
CA 2244110
The invention relates to methods of and compositions for vaccinating a mammal against a disease, wherein a mixture is administered which includes (i) a nucleic acid which encodes a first epitope and (ii) a peptide containing a second epitope such that both of the nucleic acid and the second epitope are taken up by and the nucleic acid is expressed in a professional antigen presenting cell of the mammal, and the first and second epitopes are processed in the cell such that an immune response is elicited in the mammal to the epitopes.
L'invention concerne des procédés et des compositions pour vacciner un mammifère contre une maladie. Ce procédé consiste à administrer un mélange qui comprend (i) un acide nucléique qui code un premier épitope et (ii) un peptide contenant un deuxième épitope de telle sorte que l'acide nucléique et le deuxième épitope sont capturés et l'acide nucléique est exprimé dans une cellule présentant un antigène professionnel du mammifère. Par ailleurs, les premier et deuxième épitopes sont traités dans la cellule, de telle sorte qu'une réponse immunitaire aux épitopes est déclenchée chez le mammifère .
Cobra Therapeutics Limited
Kirby Eades Gale Baker
M.l. Laboratories Plc
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