Novel methylenebisphosphonic acid derivatives

C - Chemistry – Metallurgy – 07 – F

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C07F 9/40 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2062735

Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R1, R2, R3 and R4 independently are C1-C22-alkyl, C2-C22-alkenyl, C2-C22-alkynyl, C3-C10-cycloalkyl, C3-C10- cycloalkenyl, aryl, aralkyl, silyl or hydrogen, whereby in the formula (I) at least one of the groups R1, R2, R3 and R4 is hydrogen and at least one of the groups R1, R2, R3 and R4 is different from hydrogen, Q1 is hydrogen, fluorine, chlorine, bromine or iodine, and Q2 is chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and optically active isomers, of the compounds, as well as the pharmaceutically acceptable salts of the compounds.

Dérivés nouveaux d'acide bisphosphonique pharmaceutiquement actifs de formule (I) dans laquelle R1, R2, R3 et R4 sont indépendamment alkyle C1-C22, alkényle C2-C22, alkynyle C2-C22, cycloalkyle C3-C10, cycloalkényle C3-C10, aryle, aralkyle, silyle, ou hydrogène; dans la formule (I), au moins un des groupes R1, R2, R3 et R4 est hydrogène et au moins un des groupes R1, R2, R3 et R4 est différent de l'hydrogène, Q1 est hydrogène, fluor, chlore, brome, ou iode, et Q2 est chlore, brome ou iode, y compris les stéréoisomères, tels que les isomères géométriques et les isomères optiquement actifs, des composés, ainsi que les sels pharmaceutiquement acceptables des composés.

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