C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2398743
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.
La présente invention concerne l'identification et l'isolation de nouveaux épitopes de la classe II du complexe majeur d'histocompatibilité dérivés de l'antigène du cancer, NY ESO-1. Ces nouveaux épitopes dérivés de NY-EsO-1 sont reconnus par les lymphocytes T de CD4?+¿ selon une manière restreinte à la classe II de l'antigène HLA, notamment restreinte à HLA-DR ou HLA-DP. Les produits du gène sont des candidats porteurs d'espoir dans des stratégies immunothérapeutiques de prévention, traitement et diagnostic des patients atteints d'un cancer.
Rosenberg Steven A.
Wang Rong-Fu
Zeng Gang
R. William Wray & Associates
The Government Of The United States Of America
LandOfFree
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