Novel mhc ii associated peptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2498854

The present invention provides novel naturally-processed antigenic peptides which are candidate tumor antigens in melanoma and other tumors. These antigenic peptides are presented by human MHC class II HLA-DR molecules. They originate from the translation factor eIF-4A, the IFN-gamma-inducible protein p78, the cytoskeletal protein vimentin and the iron~binding surface protein melanotransferrin. The antigenic peptides of the present invention can be used as markers in diagnosis of the respective tumors and in therapy as anti-tumor vaccines.

La présente invention concerne de nouveaux peptides antigéniques traités naturellement, constituant des antigènes tumoraux potentiels dans les mélanomes et d'autres tumeurs. Ces peptides antigéniques sont présentés par les molécules humaines HLA-DR du MHC de classe II. Ils sont générés par le facteur de traduction eIF-4A, la protéine p78 inductible par IFN-gamma, la vimentine, une protéine cytosquelettique, et la mélanotransferrine, une protéine de surface de fixation du fer. Les peptides antigéniques de l'invention peuvent être utilisés en tant que marqueurs dans le diagnostic de tumeurs correspondantes, et en thérapie en tant que vaccins anti-tumoraux.

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