C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) C12P 7/18 (2006.01) C12P 7/46 (2006.01) C12P 17/04 (2006.01) C12P 17/10 (2006.01) C12N 1/32 (2006.01) C12N 9/10 (2006.01)
Patent
CA 2751280
The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
La présente invention concerne des souches bactériennes capables d'utiliser le glycérol en tant que source de carbone pour la production par fermentation d'acide succinique, lesdites souches étant génétiquement modifiées de manière à comprendre une dérégulation de leur activité enzymatique pyruvate-formate-lyase endogène, ainsi que des procédés de production d'acides organiques, notamment d'acide succinique, utilisant un tel micro-organisme. La présente invention concerne également le traitement en aval des acides organiques produits par chromatographie à échange de cations.
Abendroth Gregory von
Ernst Hansgeorg
Gurski Hans
Haefner Stefan
Hollmann Rajan
Basf Se
Robic
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