Novel minor groove binders

Details Novel minor groove binders Novel minor groove binders

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2664847

There is provided compounds of formula (I), wherein R1, R11, R12, Qa, X, Qb, Qc, A and D have meanings given in the description, or a pharmaceutically acceptable salt or solvate thereof, which compound, salt or solvate binds to the minor groove of DNA.

La présente invention concerne des composés de formule (I), dans laquelle R1, R11, R12, Qa, X, Qb, Qc, A et D ont les sens qui leurs sont donnés dans la description, ou un sel ou un solvate pharmaceutiquement acceptable de ceux-ci, ledit composé, sel ou solvate se liant au sillon mineur de l'ADN.

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