Novel mixed amylin activity compounds

Details Novel mixed amylin activity compounds Novel mixed amylin activity compounds

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61P 3/00 (2006.01) A61P 3/08 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2320962

Compounds which inhibit certain activities of amylin but which also act as amylin agonists with respect to other amylin activities are disclosed. Such compounds are useful in treating disturbances in fuel metabolism in mammals, including but not limited to, diabetes, mellitus, including Type I diabetes and Type II diabetes, impaired glucose tolerance, insulin resistance and Syndrome X. The present invention also relates to methods of treating Type I diabetes, beneficially regulating gastrointestinal motility, treating impaired glucose tolerance, treating postprandial hyperglycemia, treating obesity and treating Syndrome X, comprising administration of a therapeutically effective amount of certain compounds, as described herein.

L'invention concerne des composés qui inhibent certaines activités de l'amyline, mais qui agissent également en tant qu'agonistes de l'amyline, par rapport à d'autres activités de celle-ci. De tels composés sont utiles dans le traitement de troubles du métabolisme glucidique chez les mammifères, ces troubles comprenant, sans y être limités, le diabète sucré, notamment les diabètes de type I et II, le dysfonctionnement de la tolérance au glucose, l'insulino-résistance et le syndrome X. La présente invention concerne également des procédés de traitement du diabète de type I, de régulation bénéfique de la motilité gastro-intestinale, du traitement du dysfonctionnement de la tolérance au glucose, de l'hyperglycémie postprandiale, de l'obésité et du syndrome X, ces procédés consistant à administrer une dose efficace sur le plan thérapeutique de certains composés, tels ceux que décrits ici.

Affiliated with

Also associated with

Rating

Novel mixed amylin activity compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel mixed amylin activity compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel mixed amylin activity compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1779373