Novel modification of medical prostheses

A - Human Necessities – 61 – F

Patent

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A61F 2/00 (2006.01) A61L 2/00 (2006.01)

Patent

CA 2561496

The incorporation of one or more therapeutic agents on metallic and non- metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.

L'invention concerne l'incorporation d'un ou plusieurs agents thérapeutiques sur des prothèses médicales métalliques et non métalliques. L'agent thérapeutique peut être utilisé, par exemple, pour prévenir, traiter ou réduire les infections bactériennes et fongiques associées à ces implants. En outre, les agents thérapeutiques peuvent être utilisés pour produire d'autres effets thérapeutiques bénéfiques. Plus particulièrement, un revêtement thérapeutique bicouche est appliqué en deux étapes. Par ailleurs, des agents thérapeutiques non antimicrobiens peuvent être incorporés dans ce revêtement en vue du traitement, de la prévention, de la modification ou de la stimulation de certaines bioactivités cliniques.

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