C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 48/00 (2006.01) C12N 15/57 (2006.01)
Patent
CA 2527361
This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.
La présente invention se rapporte à de nouvelles molécules de corine modifiées, ou à des fragments ou des dérivés de celles-ci, qui contiennent une séquence d'activation de substitution. Les molécules de corine modifiées sont clivées au niveau de la séquence d'activation de substitution, ce qui génère des molécules de corine activées, ou des fragments ou des dérivés de celles-ci, qui présentent l'activité fonctionnelle de molécules de corine de type sauvage, d'origine naturelle. Les molécules de corine modifiées peuvent servir à traiter divers maladies ou troubles, notamment l'insuffisance cardiaque congestive et l'infarctus du myocarde aigu.
Marks & Clerk
Schering Aktiengesellschaft
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