C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61P 11/00 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) C07D 271/06 (2006.01) C07D 401/04 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2723904
Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.
La présente invention concerne des composés qui activent un récepteur de la sphingosine-1-phosphate de sous-type 1. Certains composés activent sélectivement le récepteur de sous-type 1 par rapport au récepteur de la sphingosine-1-phosphate de sous-type 3. Linvention concerne également les utilisations et les procédés des composés de linvention pour le traitement détats pathologiques dans lesquels lactivation, lagonisme, linhibition ou lantagonisme de S1P1 est médicalement indiqué.
Brown Steven
Guerrero Miguel A.
Peng Xuemei
Poddutoori Ramulu
Roberts Edward
Goudreau Gage Dubuc
The Scripps Research Institute
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