C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) C12N 9/16 (2006.01) C12Q 1/44 (2006.01)
Patent
CA 2457611
The invention relates to the field of biology, genetics and medicine and to novel methods of detecting, characterising and/or treating (or managing) neurodegenerative pathologies, particularly amyotrophic lateral sclerosis. Said invention also relates to methods of identifying or screening active compounds in said pathologies. Moreover, the invention relates to compounds, genes, cells, plasmids or compositions that can be used to carry out the above-mentioned methods. In particular, the invention outlines the role of PDE4B in said pathologies and the use thereof as a therapeutic, diagnostic or experimental target.
La présente invention concerne le domaine de la biologie, de la génétique et de la médecine. Elle concerne notamment de nouvelles méthodes pour la détection, la caractérisation et/ou le traitement (ou la prise en charge) de pathologies neurodégénératives, notamment de la sclérose latérale amyotrophique. L'invention concerne également des méthodes pour l'identification ou le screening de composés actifs dans ces pathologies. L'invention concerne également les composés, gènes, cellules, plasmides ou compositions utiles pour la mise en oeuvre des méthodes ci-dessus. L'invention décrit notamment le rôle de PDE4B dans ces pathologies et son utilisation comme cible thérapeutique, diagnostique ou expérimentale.
Aiet Ikhlef Ali
Resink Annelies
Schweighoffer Fabien
Exonhit Therapeutics Sa
Robic
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