Novel molecule and diagnosis method

Details Novel molecule and diagnosis method Novel molecule and diagnosis method

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2331455

A substantially isolated dimer comprising first and second cross-linked polypeptides, wherein said polypeptides comprise the extracellular domain portions of the HLA-B27 heavy chain and are capable of binding a HLA-B27 epitope, or a substantially isolated functional dimeric or multimeric analogue thereof which is capable of binding said HLA-B27 epitope and/or competes for binding to a specific receptor for said dimer. The dimer can be used to determine the onset of, or predisposition to a spondyloarthropathy. The dimer can also be used as a treatment or prophylactic for a spondyloarthropathy.

L'invention se rapporte à un dimère sensiblement isolé comportant un premier et un second polypeptide réticulé qui comprennent les parties du domaine extracellulaire de la chaîne lourde de l'antigène HLA-B27 et sont susceptibles de se lier à un épitope de HLA-B27, ou à un analogue dimère ou multimère fonctionnel sensiblement isolé qui est susceptible de se lier audit épitope de HLA-B27 et/ou est en concurrence pour se lier à un récepteur spécifique associé audit dimère. Le dimère de cette invention peut servir à déterminer l'apparition d'une spondyloarthropathie ou la prédisposition à une telle maladie. Ce dimère peut également servir d'agent thérapeutique ou prophylactique de la spondyloarthropathie.

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