C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2320392
Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD- 4Y, CARD-4Z, and murine CARD-4L fusion proteins, antigenic peptides and anti- CARD-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, and anti- murine CARD-4L antibodies. The invention also provides CARD-3, CARD-4L, CARD- 4S, CARD-4Y, CARD-4Z, and murine CARD-4L nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L gene has been introduced or disrupted. The invention further provides CARD-3 and CARD-4 target proteins that bind to CARD-3 or CARD-4 and allelic variants of human CARD-4. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
L'invention concerne de nouveaux polypeptides, protéines et molécules d'acide nucléique CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z et CARD-4L de souris. Outre les protéines isolées CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, et CARD-4L de souris, l'invention concerne également des protéines de fusion CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z et CARD-4L de souris, des peptides antigéniques et des anticorps anti-CARD-3, anti-CARD-4L, anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z et anti-CARD-4L de souris. L'invention concerne également des molécules d'acide nucléique CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z et CARD-4L de souris, des vecteurs d'expression recombinants contenant une molécule d'acide nucléique selon l'invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains chez lesquels un gène CARD-3, CARD-4L, CARD-4S, CARD-4Y CARD-4Z et CARD-4L de souris a été introduit ou disloqué. L'invention concerne également des protéines cibles CARD-3 et CARD-4 qui se lient au CARD-3 ou CARD-4 et des allèles de CARD-4 humain. L'invention concerne également des méthodes de diagnostic, de ciblage et de traitement utilisant les compositions selon l'invention.
Millennium Pharmaceuticals Inc.
Smart & Biggar
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