Novel molecules of the herpes virus-entry-mediator-related...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2340686

Novel TANGO-69-receptor polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length TANGO-69-receptor proteins, the invention further provides isolated TANGO-69-receptor fusion proteins, antigenic peptides and anti-TANGO-69-receptor antibodies. The invention also provides TANGO-69-receptor nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a TANGO-69-receptor gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne de nouveaux polypeptides, protéines et molécules d'acides nucléiques du récepteur de TANGO-69. Outre les protéines du récepteur de TANGO-69 pleine longueur isolées, l'invention concerne des protéines de fusion du récepteur de TANGO-69 isolées, des peptides antigéniques et des anticorps anti-récepteur de TANGO-69. L'invention concerne également des molécules d'acides nucléiques du récepteur de TANGO-69, des vecteurs d'expression recombinés contenant une molécule d'acide nucléique de l'invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels un gène du récepteur de TANGO-69 a été introduit ou placé par disruption. L'invention concerne également des procédés diagnostiques, de criblage et thérapeutiques utilisant des compositions de l'invention.

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