C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) C07H 21/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2299055
Novel Tango-77 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Tango-77 proteins, the invention further provides isolated Tango-77 fusion proteins, antigenic peptides and anti-Tango-77 antibodies. The invention also provides Tango-77 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Tango-77 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
L'invention a trait à de nouvelles molécules d'acides nucléiques, protéines et à de nouveaux polypeptides de type Tango-77. Outre les protéines Tango-77 complètes isolées, l'invention concerne encore des protéines hybrides Tango-77 isolées, des peptides antigéniques et des anticorps dirigés contre la Tango-77. L'invention traite également de molécules d'acides nucléiques de type Tango-77, de vecteurs d'expression recombinants renfermant une molécule d'acides nucléiques selon l'invention, des cellules hôtes dans lesquelles lesdits vecteurs d'expression ont été introduits ainsi que des animaux transgéniques non humains dans lesquels un gène de Tango-77 a été introduit ou lysé. L'invention concerne enfin des procédés thérapeutiques, diagnostiques et de ciblage utilisant des compositions selon l'invention.
Millennium Biotherapeutics Inc.
Smart & Biggar
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