Novel molecules of the tnf receptor superfamily and uses...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/02 (2006.01) A61K 38/03 (2006.01) A61K 38/04 (2006.01) A61K 38/10 (2006.01) C07K 14/715 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2304746

Novel TRL polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length TRL proteins, the invention further provides isolated TRL fusion proteins, antigenic peptides and anti-TRL antibodies. The invention also provides TRL nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a TRL gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Cette invention se rapporte à de nouveaux polypeptides, à de nouvelles protéines et à de nouvelles molécules d'acide nucléique apparentés aux récepteurs du facteur de nécrose tumorale (TNF), ces polypeptides, protéines et molécules étant appelés TRL. Outre des protéines TRL complètes isolées, cette invention présente des protéines de fusion TRL, des peptides antigéniques et des anticorps anti-TRL isolés. Cette invention se rapporte également à des molécules d'acide nucléique TRL, à des vecteurs d'expression recombinés contenant une molécule d'acide nucléique de cette invention, à des cellules hôtes dans lesquelles ont été introduits ces vecteurs d'expression et à des animaux transgéniques non humains dans lesquels un gène TRL a été introduit ou dissocié. Des procédés de diagnostic, de tri et de thérapie utilisant les compositions de cette invention sont également proposés.

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