Novel molecules of the tnf receptor superfamily and uses...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/28 (2006.01) A01K 67/027 (2006.01) A61K 38/19 (2006.01) C07H 21/04 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/06 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2318743

Novel STRIFE1 and STRIFE2 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length STRIFE1 and STRIFE2 proteins, the invention further provides isolated STRIFE1 and STRIFE2 fusion proteins, antigenic peptides and anti-STRIFE1 or STRIFE2 antibodies. The invention also provides STRIFE1 and STRIFE2 nucleic acid molecules, recombinant expression vectors containing nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a STRIFE1 or STRIFE2 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

L'invention porte sur de nouveaux polypeptides, de nouvelles protéines et molécules d'acide nucléique de la superfamille du récepteur du facteur de nécrose tumorale "STRIFE1" et "STRIFE2". Outre les protéines complètes et isolées STRIFE1 et STRIFE2, l'invention porte également sur des protéines de fusion STRIFE1 et STRIFE2, sur des peptides antigéniques et sur des anticorps anti-STRIFE1 ou STRIFE2. L'invention porte encore sur des molécules d'acide nucléique STRIFE1 et STRIFE2, sur des vecteurs d'expression de recombinaison contenant les molécules d'acide nucléique précitées, sur des cellules hôtes dans lesquelles ont été introduits les vecteurs d'expression, et sur des animaux transgéniques dans lesquels a été introduit ou dissocié un gène STRIFE1 ou STRIFE2. L'invention porte enfin sur des méthodes thérapeutiques, diagnostiques et de test utilisant ces compositions.

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