Novel monoclonal antibody and use of the same

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 3/10 (2006.01) A61P 5/48 (2006.01) A61P 15/00 (2006.01) A61P 25/02 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 43/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C40B 30/06 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2660330

It is intended to provide an anti-PAC1 monoclonal antibody capable of recognizing PAC1 having a native structure, a PAC1 activity regulator (in particular, an activity inhibitor) containing the above antibody, a preventive/remedy for a disease relating increasing physiological activity of PAC1 which contains the above antibody, a diagnostic for a disease relating to an abnormality in the PAC1 activity which contains the above antibody, and a method of screening a substance regulating the expression of PAC1 by using the above antibody and a cell expressing PAC1.

La présente invention concerne un anticorps monoclonal anti-PAC1 capable de reconnaître le gène PAC1 de structure native, un régulateur de l'activité de PAC1 (en particulier, un inhibiteur de l'activité) contenant l'anticorps susmentionné, un agent de prévention et un remède qui permettent de traiter une maladie liée à l'accroissement de l'activité physiologique de PAC1 et contiennent l'anticorps susmentionné, un agent de diagnostic d'une maladie liée à une anomalie de l'activité de PAC1 qui contient l'anticorps susmentionné, un procédé de criblage d'une substance régulant l'expression de PAC1 au moyen de l'anticorps susmentionné et une cellule exprimant PAC1.

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