C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 5/18 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2204731
A novel monoclonal antibody inhibiting the activity of type II phospholipase A2. The antibody inhibits the activity of human type II phospholipase A2 and those of ape type II phospholipase A2 and/or mouse type II phospholipase A2, which makes it not only clinically useful but also usable as such in preclinical tests with the use of ape or mouse. The antibody, which has a completely novel characteristic of releasing type II phospholipase A2 bound to cell membrane, seems to strongly inhibit the type II phospholipase A2 activity via a novel mechanism. A protein containing the monoclonal antibody or a part of the same and being usable as a remedy for heart infarction, brain infarction, etc. in which type II phospholipase A2 participates.
L'invention concerne un nouvel anticorps monoclonal inhibant l'activité de la phospholipase A2 de type II. L'anticorps présenté inhibe l'activité de la phospholipase A2 de type II humaine ainsi que l'activité de la phospholipase A2 de type II du singe et/ou de la phospholipase A2 de type II de la souris, ce qui permet de l'utiliser non seulement de façon clinique mais également dans des test précliniques effectués sur des singes ou des souris. Cet anticorps, lequel a une faculté complètement nouvelle de libération de la phospholipase A2 de type II liée à la membrane cellulaire, semble fortement inhiber l'activité de la phospholipase A2 de type II par l'intermédiaire d'un nouveau mécanisme. L'invention concerne également une protéine contenant le nouvel anticorps monoclonal ou une partie de celui-ci et pouvant être utilisée en tant que remède pour soigner l'infarctus du myocarde, l'infarctus cérébral et autres lésions dans lesquelles la phospholipase A2 de type II joue un rôle.
Kawauchi Yasushi
Masuho Yasuhiko
Takasaki Jun
Yasunaga Tomoe
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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