Novel monoclonal antibody recognizing cell surface antigen cd14

Details Novel monoclonal antibody recognizing cell surface antigen cd14 Novel monoclonal antibody recognizing cell surface antigen cd14

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2264509

A monoclonal antibody which recognizes lipopolysaccharide binding site of macrophage cell surface receptor CD14 and has binding activity to monocyte or macrophage cells. The monoclonal antibody suppresses the production of an inflammatory mediator such as TNF, IL-6 or NO at early stages by recognizing CD14, and competitively inhibiting its binding with LPS. Therefore, it is useful for pathology analysis and the treatment of sepsis.

L'invention porte sur un anticorps monoclonal qui reconnaît le site de liaison du lipopolysaccharide, soit le récepteur CD14, situé à la surface du macrophage. L'anticorps se lie aux monocytes ou aux macrophages. L'anticorps monoclonal inhibe la production de médiateurs de l'inflammation tels que le TNF, l'IL-6 ou le NO, dès les premières étapes, en reconnaissant le CD14 et en entrant en compétition avec le LPS (inhibition compétitive). Par conséquent, il s'avère utile pour analyser les maladies et traiter la septicémie.

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