C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/51 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2267666
A novel gene, DD-10, and its encoded polypeptide chain, DD-10, expressed during early onset of morphogen-induced mammalian tissue morphogenesis, now has been discovered. Accordingly, the invention identifies a new gene which is a novel biological marker of cell differentiation and tissue morphogenesis, particularly of chondroblast or osteoblast cell differentiation and bone tissue morphogenesis. Disclosed are: (a) methods and compositions for screening for and producing morphogen analogs; (b) novel morphogen analogs; (c) downstream inducers of morphogenesis; (d) a novel marker for evaluating morphogen or morphogen analog dosing; and (e) therapeutic methods and compositions using these analogs and/or downstream inducers.
Suite à la découverte d'un nouveau gène, DD-10, et de sa chaîne polypeptidique codée, DD-10, dont l'expression intervient au cours de l'apparition précoce d'une morphogenèse de tissu mammalien induite par des éléments morphogènes, on identifie un nouveau gène tenant lieu de nouveau marqueur biologique en différenciation cellulaire et en morphogenèse de tissu, particulièrement la différenciation des chondroblastes ou des ostéoblastes et la morphogenèse de tissu osseux. Sont décrits: (a) procédés et compositions pour cribler et élaborer des analogues morphogènes; (b) nouveaux analogues morphogènes; (c) inducteurs de morphogenèse en aval; (d) nouveau marqueur pour évaluer le dosage des éléments morphogènes ou des analogues morphogènes; et (e) procédés et compositions thérapeutiques à base des analogues et/ou des inducteurs en aval considérés.
Ichijo Hidenori
Sampath Kuber T.
Takeda Kohsuke
Creative Biomolecules Inc.
Japanese Foundation For Cancer Research
Mbm Intellectual Property Law Llp
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