Novel mouse cxc chemokine receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2279461

A DNA encoding a polypeptide comprising the whole amino acid sequence described in SEQ. ID NO: 17 of the Sequence Listing or a part of the same or a polypeptide containing the above polypeptide which has a receptor activity capable of binding to mouse PBSF/SDF-1; a polypeptide encoded by this DNA and having a receptor activity capable of binding to mouse PBSF/SDF-1; cells expressing this polypeptide and human CD4 protein; and a method for screening an AIDS onset inhibitor, an HIV-1 infection inhibitor, etc. which comprises using the above-mentioned cells. Thus the invention provides a novel mouse CXC chemokine receptor gene which is useful in studies on a remedy for AIDS or the mode of action in the infection with HIV-1, a method for screening an HIV-1 infection inhibitor, etc.

L'invention a trait à un ADN codant un polypeptide comportant tout ou partie de la séquence aminoacide décrite dans SEQ ID N· 17 du catalogue de séquences ou bien un polypeptide contenant le polypeptide susmentionné dont l'activité de récepteur est capable d'une liaison au PBSF/SDF-1 murin. Elle concerne également un polypeptide codé par cet ADN et dont l'activité de récepteur est capable d'une liaison au PBSF/SDF-1 murin, des cellules exprimant ce polypeptide et la protéine humaine CD4. Elle porte, en outre, sur une méthode de criblage d'un inhibiteur d'installation du SIDA, d'un inhibiteur de l'infection à VIH, etc., laquelle méthode fait appel aux cellules susmentionnées. Cette invention porte donc sur un nouveau gène de récepteur de chimiokine CXC murin, des plus utile dans le cadre de la recherche médicamenteuse contre le SIDA ou du mode opératoire en matière d'infection à VIH, ainsi que sur une méthode de criblage d'un inhibiteur de l'infection à VIH, etc.

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