C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/404 (2006.01) A61K 31/437 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2655014
The present invention is directed to novel multicyclic molecules of Formula (IIIIa)* that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP3 VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
La présente invention porte sur de nouvelles molécules multicycliques qui assurent la médiation d'une activité enzymatique. En particulier, les composés peuvent être efficaces dans le traitement de maladies ou d'états liés à des maladies se rapportant à l'activité de PARP, VEGFR2, et des enzymes MLK3, notamment, les maladies neurodégénératives, l'inflammation, l'ischémie et le cancer.
Chatterjee Sankar
Dandu Reddeppareddy
Diebold James L.
Dunn Derek
Hudkins Robert L.
Cephalon Inc.
Goudreau Gage Dubuc
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