Novel multicyclic compounds and the use thereof

Details Novel multicyclic compounds and the use thereof Novel multicyclic compounds and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61P 43/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 243/00 (2006.01) C07D 307/00 (2006.01) C07D 471/14 (2006.01) C07D 491/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2409758

The present invention is directed to novel multicyclic molecules of formula (Ia) that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

L'invention porte sur de nouveaux composés multicycliques médiateurs de l'activité enzymatique. Lesdits composés peuvent en particulier être efficaces dans le traitement de maladies ou de troubles liés à l'activité des enzymes PARP, VEGFR2, et MLK3, dont par exemple les maladies neurodégénératives, les inflammations, l'ischémie, et le cancer.

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