Novel multifunctional cytokines

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/54 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/55 (2006.01) C12N 15/62 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2531773

The present invention relates to a novel fusion protein with the formula X-Y, or Y-X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating polypeptide different from X. The present invention also relates to a nucleic acid molecule encoding such a fusion protein and a vector comprising such a nucleic acid molecule. The present invention also provides infectious viral particles and host cells comprising such a nucleic acid molecule or such a vector as well as a process for producing such infectious viral particles. The present invention also relates to a method for recombinantly producing such a fusion protein. Finally, the present invention also provides a pharmaceutical composition comprising such a fusion protein, a nucleic acid molecule, a vector, infectious viral particles and a host cell as well as the therapeutic use thereof.

L'invention concerne une nouvelle protéine de fusion de formule X-Y, ou Y-X, X représentant un premier polypeptide immunorégulateur et Y représentant un second polypeptide immunorégulateur différent de X. Cette invention concerne également une molécule d'acides nucléiques codant une telle protéine et un vecteur comprenant une telle molécule d'acides nucléiques. Elle concerne aussi des particules virales infectieuses et des cellules hôtes comprenant une telle molécule d'acides nucléiques et un tel vecteur en tant que procédé de production de particules virales infectieuses. Elle concerne enfin un procédé de production recombinant d'une protéine de fusion et de production d'une composition pharmaceutique contenant une protéine de fusion, une molécule d'acides nucléiques, un vecteur, des particules virales infectieuses et une cellule hôte, ainsi que l'utilisation thérapeutique de cette composition.

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