Novel multipotent stem cells and use thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61P 9/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2543794

Disclosed is an isolated bone marrow stem cell (MBSC) having undetectable or low levels of selected cell markers including those typical of endothelial, neuronal and smooth muscle cells. Also disclosed are grafts pharmaceutical products that include such cells. Methods of making the BMSCs are also provided. The invention has a wide spectrum of useful applications including use in the prevention and treatment of cardiovascular disease.

L'invention concerne une cellule souche de moelle osseuse isolée (BMSC) possédant des niveaux indétectables ou faibles de marqueurs cellulaires sélectionnés, dont ceux typiques des cellules endothéliales, neuronales et des muscles lisses. L'invention porte également sur des greffons et sur des produits pharmaceutiques comprenant lesdites cellules. Des méthodes de fabrication des BMSC sont également décrites. Le tout trouve une plage étendue d'applications, dont l'utilisation dans la prévention et le traitement de maladies cardiovasculaires.

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