Novel mutant allergens

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/29 (2006.01) A61K 39/35 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01) C07K 14/415 (2006.01) C07K 14/435 (2006.01) C07K 16/16 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) A61K 38/11 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2429172

Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are non-naturally occurring mutants of naturally-occurring allergens. The overall .prop.-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.

L'invention a pour objet de nouveaux allergènes recombinants qui présentent des mutations multiples et une affinité de liaison IgE réduite. Ces allergènes sont des mutants non-naturels issus d'allergènes naturels. La structure tertiaire globale du squelette de carbones .alpha. est presque entièrement préservée. L'invention porte également sur une méthode permettant de préparer ces allergènes recombinants et sur leur utilisation.

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