Novel n-(2-amino-phenyl)-amide derivatives

Details Novel n-(2-amino-phenyl)-amide derivatives Novel n-(2-amino-phenyl)-amide derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) A61K 31/167 (2006.01) A61K 31/255 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/4453 (2006.01) A61K 31/541 (2006.01) A61P 35/02 (2006.01) C07C 255/60 (2006.01) C07C 271/28 (2006.01) C07C 309/66 (2006.01) C07D 213/75 (2006.01) C07D 295/13 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2711995

The present invention provides novel compounds of the general formula (I), and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments, containing them. The compounds of the present invention show anti-proliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion. The invention also covers the use of such compounds for the treatment of diseases such as cancer and for the manufacture of corresponding medicaments.

La présente invention concerne de nouveaux composés de formule générale (I), et leurs sels pharmaceutiquement acceptables, des procédés pour la fabrication de ces nouveaux composés et des médicaments les renfermant. Les composés de la présente invention présentent une activité antiproliférative et inductrice de différenciation, ce qui aboutit à l'inhibition de la prolifération des cellules tumorales, à l'induction de l'apoptose et à l'inhibition d'une invasion. L'invention a également pour objet l'utilisation de tels composés pour le traitement de maladies telles que le cancer et pour la fabrication de médicaments correspondants.

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