C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2293565
The invention concerns compounds selected among the set consisting of (i) compounds of formula (I) in which X represents a halogen atom; A represents a group -NH-(CH2)n-NH-CO-, -NH-CH2- or (a); Q represents a group (Het 1), (Het 2), (Het 3) or (Het 4); R1 is hydrogen, halogen, C1-C3 alkyl or C1-C5 1- oxoalkyl; R2 is H or OH; and n is 2, 3, or 4; and (ii) their addition salts. The invention also concerns their preparation method and their use in therapy, in particular for treating pathologies involving bradykinin.
La présente invention concerne des composés choisis parmi l'ensemble constitué par (i) les composés de formule (I), dans laquelle X représente un atome d'halogène, A représente un groupe -NH-(CH¿2?)¿n?-NH-CO-, -NH-CH¿2?- ou (a); Q représente un groupe (Het 1), (Het 2), (Het 3) ou (Het 4); R¿1? est hydrogène, halogène, alkyle en C¿1?-C¿3? ou 1-oxoalkyle en C¿1?-C¿5?; R¿2? est H ou OH; et n est 2, 3, ou 4; et (ii) leurs sels d'addition. Elle concerne également leur procédé de préparation et leur utilisation en thérapeutique, notamment vis-à-vis des pathologies mettant en cause la bradykinine.
Barth Martine
Bondoux Michel
Dodey Pierre
Houziaux Patrick
Ou Khan
Fournier Industrie Et Sante
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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