Novel n-substituted naphthofused lactams

Details Novel n-substituted naphthofused lactams Novel n-substituted naphthofused lactams

C - Chemistry, Metallurgy

07

D

C07D 403/00 (2006.01) A61K 31/395 (2006.01) C07D 223/14 (2006.01) C07D 401/00 (2006.01) C07D 403/10 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 413/14 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2196877

Disclosed are novel N-substituted naphthofused lactams and salts thereof of formula (I). Compounds of general formula (I) possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.

L'invention concerne de nouveaux lactames naphtofusionnés à substitution N ainsi que leurs sels de formule (I). Les composés de formule (I) présentent la capacité de stimuler la libération de l'hormone de croissance endogène. Ainsi, on peut utiliser ces composés dans le traitement d'états nécessitant une stimulation de la production ou de la sécrétion de l'hormone de croissance tels que chez des individus présentant une carence en hormone de croissance ou lorsque l'on veut augmenter les niveaux d'hormone de croissance dans le plasma, par exemple chez des patients agés ou chez des animaux d'élevage.

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