Novel n-substituted pyrrolidine derivatives and process for...

Details Novel n-substituted pyrrolidine derivatives and process for... Novel n-substituted pyrrolidine derivatives and process for...

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2273253

Novel N-substituted pyrrolidine derivatives having a highly selective and potent antagonism against smooth muscle muscarine receptors and being useful for the treatment of irritable bowel syndrome and the like, characterized by being represented by general formula (1) (wherein R represents a hydrogen atom, a halogen atom, or a lower alkoxy group and a process for preparing the same.

L'invention concerne de nouveaux dérivés de pyrrolidine N-substitués présentant un antagonisme hautement sélectif et puissant contre des récepteurs de muscarine du muscle lisse, et s'utilisant dans le traitement du syndrome du côlon irritable d'autres affections similaires, et caractérisés par le fait qu'ils sont représentés par la formule générale (1) (dans laquelle R désigne un atome d'hydrogène, un atome d'halogène, ou un groupe alcoxy inférieur); l'invention concerne également un procédé de préparation de ces dérivés.

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