C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07C 323/25 (2006.01) C07C 331/28 (2006.01) C07K 17/06 (2006.01)
Patent
CA 2199145
N3S2 chelating ligands of formula (1) in which R, R1, R2, and n are as defined in claim 1, can be chelated to a radiodetectable element, Tc or Re, and are useful for radiolabelling peptides. A group of peptides especially useful are somatostatin derivatives which are valuable in the selective detection or treatment of tumours with somatostatin receptors.
L'invention concerne de nouveaux ligands chélateurs de type N3S2 de formule (1), dans laquelle R, R<1>, R<2>, et n sont définis dans la revendication 1, pouvant être chélatés à un élément radiodétectable Tc ou Re et utiles dans le radiomarquage des peptides. Un ensemble de peptides s'avérant particulièrement intéressants sont les dérivés de la somatostatine utilisés dans la détection ou le traitement de manière sélective de tumeurs présentant des récepteurs de la somatostatine.
Dufour Jean-Marc
Flanagan Richard J.
Hogan Keith T.
Jubilant Draximage Inc.
Mccarthy Tetrault Llp
Merck Frosst Canada Inc.
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