Novel naphthyridine derivatives

Details Novel naphthyridine derivatives Novel naphthyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2272068

Naphthyridine derivatives of general formula (I) and acid addition salts thereof, which exhibit an inhibitory activity against acyl-CoA cholesterol acyltransferase and therefor are useful as preventive and therapeutic agents for hyperlipemia, arteriosclerosis and diseases relate thereto: wherein A is an optionally substituted pyridine ring; X is -N(R2)-CO- (wherein R2 is hydrogen, alkyl, substituted alkyl or the like); Z is a free bond, -NH-, C1 or C2 alkylene or -CH=CH-; Y is aryl or substituted aryl; and L is alkyl, substituted alkyl, aryl, substituted aryl or the like.

Dérivés de naphthyridine représentés par la formule générale (1) et leurs sels d'apport acide présentant une activité d'inhibition contre acyle-CoA cholestérol acyltransférase et étant, de ce fait, utiles en tant qu'agents préventifs et thérapeutiques de l'hyperlipidémie, de l'athérosclérose et de maladies associées; (1) dans laquelle A représente un noyau pyridine éventuellement substitué; X représente -N(R?2¿)-CO- (dans laquelle R?2¿ représente hydrogène, alkyle, alkyle substitué ou similaire); Z représente une liaison libre, -NH-, alkylène C¿1? ou C¿2? ou -CH=CH-; Y représente aryle ou aryle substitué; L représente alkyle, alkyle substitué, aryle, aryle substitué ou similaire.

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