Novel naphthyridine derivatives

Details Novel naphthyridine derivatives Novel naphthyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2222687

Naphthyridine derivatives represented by general formula (1) and acid-addition salts thereof, having the activity of inhibiting acyl CoA: cholesterol acyltransferases, and useful for preventing and treating hyperlipemia, arteriosclerosis and related diseases. In said formula, ring A represents an optionally substituted pyridine ring; X represents -NR2-CO-; R2 represents hydrogen, alkyl, substituted alkyl, etc.; Z represents a bond, -NH-, C1-C2 alkylene, or -CH=CH-; Y represents alkyl, substituted alkyl, aryl, substituted aryl, etc.; and B represents alkyl, substituted alkyl, aryl, substituted aryl, etc.

Dérivés de naphtyridine représentés par la formule générale (1) et leurs sels d'addition d'acide, ayant la propriété d'inhiber l'acyl CoA: cholestérol acyltransférases, utiles au traitement de l'hyperlipémie, de l'artériosclérose et des maladies associées. Dans la formule, le noyau A représente un noyau pyridine éventuellement substitué; X représente -NR?2¿-CO-; R?2¿ représente hydrogène, alkyle, alkyle substitué, etc.; Z représente une liaison, -NH-, alkylène C¿1?-C¿2? ou -CH=CH-; Y représente alkyle, alkyle substitué, aryle, aryle substitué, etc. et B représente alkyle, alkyle substitué, aryle, aryle substitué, etc.

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