Novel neuropilin/growth factor binding and uses thereof

Details Novel neuropilin/growth factor binding and uses thereof Novel neuropilin/growth factor binding and uses thereof

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2346798

Complexes of a protein selected from the group consisting of VEGF-B167, VEGF- C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP- 1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF- B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.

L'invention concerne des complexes composés d'une protéine sélectionnée dans le groupe constitué par VEGF-B¿167?, VEGF-C, VEGF-D, VEGF-B¿186? traité et leurs analogues, et du récepteur de neuropiline-1 (NP-1), du domaine extracellulaire, d'un fragment ou d'un analogue se liant au ligand de celui-ci; l'utilisation de ces complexes dans des techniques de titrage de protéines du facteur de croissance qui présentent sensiblement la même affinité de liaison pour un récepteur de surface cellulaire tel que VEGF-B¿167?, VEGF-C, VEGF-D ou VEGF-B¿186? traité, et/ou pour activer ou faire obstacle à une réaction cellulaire dans laquelle intervient VEGF-B¿167?, VEGF-C, VEGF-D et/ou VEGF-B¿186? traité; et des partenaires de liaison spécifiques de ces complexes, p. ex. des anticorps.

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