Novel nitrogenous heterocyclic compounds, preparation...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 471/18 (2006.01) A61K 31/437 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2739503

The invention relates to nitrogenous heterocyclic compounds of general formula (I) in which: R1 is a (CH2)n-NH2 radical, n being equal to 1 or 2; R2 is a hydrogen atom; R3 and R4 together form a nitrogenous heterocycle that is aromatic in nature, with 5 ring members, containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or on one of these nitrogen atoms with a (CH2)m-(C(O))P-R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 being a hydroxyl group, in which case p is equal to 1, or an amino, (C1-C6)alkyl OR (C1-C6)dialkyl amino group, or a nitrogenous heterocycle that is aromatic in nature, with 5 or 6 ring members, containing one or two nitrogen atoms and, where appropriate, an oxygen or sulphur atom; it being understood that, when the (C(O))P-R5 subgroup forms a carboxyl, amino, (C1-C6)alkyl or (C1-C6)dialkyl amino group, m is other than 0 or 1; in free form or in the form of zwitterions or of salts with inorganic or organic bases and acids which are pharmaceutically acceptable, to the preparation thereof and to the use thereof as antibacterial medicaments.

L' invention concerne des composés hétérocycliques azotés de formule générale (I) dans laquelle: R1 représente un radical (CH2)n-NH2/ n étant égal à 1 ou 2; R2 représente un atome d'hydrogène; R3 et R4 forment ensemble un hétérocycle azoté à caractère aromatique à 5 sommets renfermant 1, 2 ou 3 atomes d'azote, substitué sur cet atome d'azote ou sur l'un de ces atomes d'azote par un groupe (CH2)m- (C (0) ) P-R5, m étant égal à 0, 1, 2 ou 3, p étant égal à 0 ou 1 et R5 représentant un groupe hydroxy, auquel cas p est égal à 1, ou un groupe amino, alkyl (C1-C6) OU dialkyl (C1-C6) amino, ou un hétérocycle azoté à caractère aromatique à 5 ou 6 sommets renfermant 1 ou 2 atomes d'azote et, le cas échéant, un atome d' oxygène ou de soufre; étant entendu que lorsque le sous-groupe (C(O) )P-R5 forme un groupe carboxy, amino, alkyl (C1-C6) ou dialkyl (C1-C6) amino, m est différent de 0 ou 1; sous forme libre et sous forme de zwitterions et de sels avec les bases et les acides minéraux ou organiques pharmaceutiquement acceptables, leur préparation et leur utilisation comme médicaments antibactériens.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Novel nitrogenous heterocyclic compounds, preparation... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel nitrogenous heterocyclic compounds, preparation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel nitrogenous heterocyclic compounds, preparation... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1506645

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.