C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/14 (2006.01) A61K 31/00 (2006.01) A61K 31/351 (2006.01) A61K 31/381 (2006.01) A61K 31/445 (2006.01) A61P 35/00 (2006.01) C07C 207/04 (2006.01) C07D 211/58 (2006.01) C07D 333/42 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2723590
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
La présente invention concerne des dérivés nitroso y compris des esters dacide carboxylique et dacide phosphorique de composés hydroxy-nitrosés qui donnent des nitroxyles (HNO) dans des conditions physiologiques. Les composés et les compositions de linvention sont utiles dans le traitement et/ou la prévention de linstallation et/ou du développement de maladies ou daffections qui sont réactives à une thérapie par nitroxyle, y compris une insuffisance cardiaque, une lésion dischémie/reperfusion et un cancer.
Brookfield Frederick Arthur
Courtney Stephen Martin
Frost Lisa Marie
Kalish Vincent J.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cardioxyl Pharmaceuticals Inc.
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