Novel non-psychotropic cannabinoids

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 311/80 (2006.01) A61K 31/35 (2006.01) A61K 31/415 (2006.01) C07D 233/02 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2411585

Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S, 4S) configuration of .DELTA.6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.

L'invention concerne des nouveaux cannabinoïdes non psychotropes et des compositions pharmaceutiques renfermant ces nouveaux composés destinées à prévenir la neurotoxicité, des inflammations cérébrales, des troubles inflammatoires ou immunitaires, lesdits composés contenant comme ingrédient actif l'éniantomère (1) stéréospécifique et présentant une configuration (3S, 4S) des composés du type .DELTA.?6¿ tétrahydrocannabinol. Ces compositions sont particulièrement efficaces à des fins de soulagement et même de prévention de la neurotoxicité provoquée par des actions aiguës occasionnées au système nerveux central, notamment des traumas mécaniques, des réserves de sang réduites ou compromises comme cela peut se produire lors d'un arrêt cardiaque ou d'une congestion cérébrale ou lors d'empoisonnements. Lesdites compositions sont également efficaces dans le traitement de certains troubles inflammatoires et de maladies dégénératives chroniques caractérisées par une perte de neurones et une douleur chronique, notamment une douleur neurogène.

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