Novel nor-pregnanes for inducing hypothalamic effects

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 7/00 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) C07J 9/00 (2006.01) C07J 13/00 (2006.01) C07J 41/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2223397

The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor-pregnane steroid, or a pharmaceutical composition containing a vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

L'invention concerne un procédé pour modifier la fonction hypothalamique chez un sujet. Le procédé consiste à administrer par voie nasale une vomérophérine humaine, par exemple le stéroïde 19-nor-prégnane, ou une composition pharmaceutique contenant une vomérophérine, de manière à ce que la vomérophérine se fixe sur un récepteur neuroépithélial spécifique. Le ou les stéroïdes sont, de préférence, administrés sous la forme d'une composition pharmaceutique contenant un ou plusieurs vecteurs acceptables sur le plan pharmaceutique. L'invention concerne également des compositions pharmaceutiques contenant lesdits stéroïdes.

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