C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A01K 67/027 (2006.01) A61K 31/137 (2006.01) A61P 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12Q 1/02 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2436661
The presetn invention provides for nucleic acid sequences that encoude novel mamalian intracellular signaling polypeptides, designated MURF1, MURF3, or MA- 61. The invention also provies assay systems that may be used to detect and/or measure agents that bind the MURFI or MAFBXgene product. The present invention also provides for diagnostic and therapeutic mehtods based on the interacton between MURF1 or MAFBX and agenets that initiate signal transduction or inhibition of ubiqutination throgh binding to MURF1 or MA-61, inhibiting the mRNA expression of MURF1, MURF3, or MA-61, or inhibiting the MURF1, MURF3, or MAFBXpathway.
L'invention concerne des séquences d'acide nucléique codant de nouveaux polypeptides de signalisation intracellulaires mammaliens, appelés MURF1, MURF3, ou MA-61. Cette invention concerne également des systèmes de réseau pouvant être utilisés afin de détecter et/ou mesurer des agents liant le produit des gènes MURFI ou MAFBX. Elle concerne aussi des méthodes de diagnostic et des méthodes thérapeutiques fondées sur l'interaction entre MURF1 ou MAFBX et des agents qui lancent une transduction de signal ou une inhibition de l'ubiquitination à travers la liaison à MURF1 ou à MA-61, par inhibition de l'expression d'ARNm de MURF1, MURF3, ou MA-61, ou par inhibition de la voie de MURF1, MURF3, ou MAFBX.
Bodine Sue C.
Glass David J.
Osler Hoskin & Harcourt Llp
Regeneron Pharmaceuticals Inc.
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