Novel nucleic acid transferring agents, compositions...

Details Novel nucleic acid transferring agents, compositions... Novel nucleic acid transferring agents, compositions...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 48/00 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2353576

The invention concerns novel transfer agents, compositions containing them and their uses for transferring in vitro, in vivo or ex vivo nucleic acids into cells. More precisely, the invention concerns novel nucleic acid transfer agents comprising a hydrophobic spacer chemically bound to a polycation and to at least a hydrophilic substituent.

La présente invention se rapporte à de nouveaux agents de transfert, les compositions les contenant et leurs utilisations pour le transfert in vitro, in vivo ou ex vivo d'acides nucléiques dans les cellules. Plus précisément, la présente invention concerne des nouveaux agents de transfert d'acides nucléiques qui comprennent un espaceur hydrophobe lié chimiquement d'une part à un polycation et d'autre part à au moins un substituant hydrophile.

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