Novel nucleic acids and polypeptides related to a...

Details Novel nucleic acids and polypeptides related to a... Novel nucleic acids and polypeptides related to a...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2325462

The present invention relates to a mammalian farnesyl-directed endopeptidase, especially obtainable from a human or mouse. The polypeptide and corresponding nucleic acid are useful in a variety of ways, such as for diagnostic probes, in assays to identify agents which interfere with the endopeptidase activity and its expression, and for the screening of agents for treating cancer and other pathways in which the polypeptide is involved.

L'invention concerne une endopeptidase mammalienne dirigée sur farnésyle et que l'on peut notamment obtenir à partir d'un humain ou d'une souris. Le polypeptide et l'acide nucléique correspondant sont utilisés dans plusieurs applications, par exemple, dans des sondes diagnostiques, des dosages qui identifient les agents qui interfèrent avec l'activité de l'endopeptidase et son expression, dans le criblage des agents anticancéreux et dans d'autres voies où le polypeptide est impliqué.

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