Novel nucleotide and amino acid sequences, and assays and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2554585

Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markets of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

La présente invention a trait à de nouveaux marqueurs pour la maladie cardiaque qui sont sensibles et précis à la fois. Ces marqueurs sont exprimés de manière différente et/ou spécifique dans le tissu cardiaque, contrairement aux autres types de tissus, éventuellement et de préférence y compris le tissu musculaire. La mesure de ces marqueurs, seuls ou en combinaison, dans des échantillons de patient fournit une information dont le diagnostiqueur peut établir la corrélation avec un diagnostic probable de maladie cardiaque, comprenant la pathologie et/ou la détérioration, y compris la détérioration aiguë et/ou chronique. Les marqueurs de la présente invention, seuls ou en combinaison, présentent un degré élevé de détection différentielle entre des états de maladie cardiaque et des états de maladie non cardiaque.

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