C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2325803
An isolated, synthetic or recombinant .omega.-conotoxin peptide in which the fourth loop between cysteine residues 5 and 6 comprises SEQ ID NO: 1 or such a sequence which has undergone one or more amino acid substitutions or side chain modifications, and uses therefor. SEQ ID NO: 1 comprises the amino acid sequence SGTVGR.
Dans la présente invention, on divulgue un peptide d'.oméga.-conotoxine isolé, synthétique ou recombinant, dans lequel la quatrième boucle entre les groupes cystéine 5 et 6 comprennent la séquence SEQ ID NO:1 ou telle séquence ayant subi une ou plusieurs substitutions d'acides aminés ou des modifications des chaînes latérales. On divulgue aussi ses utilisations. La séquence SEQ ID NO:1 comprend la séquence d'acides aminés SGTVGR.
Alewood Paul Francis
Drinkwater Roger Desmond
Lewis Richard James
Nielsen Katherine Justine
Sim & Mcburney
The University Of Queensland
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