A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/32 (2006.01) A61K 9/34 (2006.01) A61K 9/52 (2006.01) A61K 31/495 (2006.01) A61K 31/4965 (2006.01) A61K 31/64 (2006.01) A61K 47/36 (2006.01) A61K 9/28 (2006.01)
Patent
CA 2306103
This invention is directed to a novel solid matrixed controlled release, oral dosage form where the dosage form contains a therapeutically effective amount of a sulfonylurea or a salt or derivative thereof in the matrix. Further, the use of an aqueous alkalizing medium affords substantially complete bioavailability of the drug from the matrix of the tablet. The core tablets may optionally be coated with a coating material in the range of 2 % to 10 % with an enteric material or with a water insoluble material like ethyl cellulose.
L'invention porte sur une forme posologique orale à matrice solide et à libération contrôlée dont la matrice contient une quantité à effet thérapeutique de sulfonylurée, ou l'un de ses sels ou dérivés. A cela s'ajoute un support alcalinisant aqueux rendant le médicament présent dans la matrice entièrement assimilable. Les comprimés peuvent éventuellement être enrobés d'une substance gastrorésistante ou hydroinsoluble telle que de l'éthylcellulose, à raison de 2 à 10 %.
Baichwal Anand R.
Bhagwat Dileep
Diehl Donald II
Bull Housser & Tupper Llp
Edward Mendell Co. Inc.
Penwest Pharmaceuticals Co.
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