Novel oncolytic adenoviral vectors

Details Novel oncolytic adenoviral vectors Novel oncolytic adenoviral vectors

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/27 (2006.01)

Patent

CA 2439115

The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order : A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.

La présente invention concerne des vecteurs adénoviraux oncolytiques et leur utilisation dans des méthodes de thérapie génique. L'invention concerne également un vecteur viral de recombinaison comprenant un squelette d'acides nucléiques adénoviraux, ledit squelette d'acides nucléiques comprenant en ordre séquentiel une ITR gauche, une séquence de signalisation de terminaison, un promoteur réceptif au E2F lié à un gène essentiel à la répétition du vecteur viral de recombinaison, un signal d'encapsidation adénoviral, et une ITR droite.

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