C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/102 (2006.01) A61K 39/40 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2204037
Opacity associated proteins and DNA encoding the same are provided by the present invention. Opacity associated proteins are membrane proteins of H. influenzae which are useful as immunogens in vaccines against infection by H. influenzae. Recombinant cells transformed with DNA encoding opacity associated proteins and vectors encoding the same are also provided and are useful in and for the preparation of vaccines against H. influenzae infection. Antibodies against opacity associated proteins are also described. Methods H. influenzae in a sample and methods of immunizing mammals against H. influenzae are also provided.
L'invention concerne des protéines associées à l'opacité et l'ADN les codant. Il s'agit de protéines de membrane de H. influenzae utiles comme immunogènes dans des vaccins protégeant de l'infection par H. influenzae. On décrit aussi des cellules recombinées transformées avec de l'ADN codant des protéines associées à l'opacité, et des vecteurs qui les codent. Ces cellules et vecteurs servent à préparer des vaccins contre l'infection par H. influenzae. On décrit aussi des anticorps opposés à ces protéines associées à l'opacité, ainsi que des procédés de détection de H. influenzae dans un échantillon ainsi que des procédés d'immunisation des mammifères contre H. influenzae.
Borden Ladner Gervais Llp
The Children's Hospital Of Philadelphia
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