G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 21/63 (2006.01) G01N 15/10 (2006.01) G01N 15/14 (2006.01) G01N 21/64 (2006.01)
Patent
CA 2341359
Instrumentation and methods for performing charged coupled device (CCD) based confocal spectroscopy with a laser spot array are provided. A sample is scanned by a plurality of excitation laser scanning spots. The scanning spots are generated, for example, by converting a laser excitation beam into an array of beams using a multiple beam generating optic, such as a Damann grating. Each scanning spot scans and excites a separate region of the sample. Fluorescent light emitted by the sample is collected and imaged onto the surface of a CCD detector that has been electronically divided into bins of pixels, with each bin corresponding to one of the scanning spots. Each bin functions as a confocal aperture in which the confocal depth of focus can be controlled by changing the dimensions of the bin. Plural CCD detectors can be used for multichannel imaging of individual wavelengths. The instrumentation and methods are useful in any spectroscopic application including microscopy and microvolume laser scanning cytometry (MLSC).
La présente invention concerne des procédés et instruments pour exécuter une spectroscopie confocale fondée sur l'utilisation d'un dispositif à couplage de charge avec une matrice à taches laser. Les procédés et les instruments selon l'invention sont utiles dans toute application spectroscopique, y compris, mais non limitée à, la microscopie et à la cytométrie par balayage laser pour microvolumes.
Dietz Louis J.
Norton Scott
Walton Ian
Sim & Mcburney
Surromed Inc.
LandOfFree
Novel optical architectures for microvolume laser-scanning... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel optical architectures for microvolume laser-scanning..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel optical architectures for microvolume laser-scanning... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1744644